Uniform semiglobal practical asymptotic stability for non-autonomous cascaded systems and applications

It is due to the modularity of the analysis that results for cascaded systems have proved their utility in numerous control applications as well as in the development of general control techniques based on ``adding integrators''. Nevertheless, the standing assumptions in most of the present literature on cascaded systems is that, when decoupled, the subsystems constituting the cascade are uniformly globally asymptotically stable (UGAS). Hence existing results fail in the more general case when the subsystems are uniformly semiglobally practically asymptotically stable (USPAS). This situation is often encountered in control practice, e.g., in control of physical systems with external perturbations, measurement noise, unmodelled dynamics, etc. This paper generalizes previous results for cascades by establishing that, under a uniform boundedness condition, the cascade of two USPAS systems remains USPAS. An analogous result can be derived for USAS systems in cascade. Furthermore, we show the utility of our results in the PID control of mechanical systems considering the dynamics of the DC motors.Comment: 16 pages. Modifications 1st Feb. 2006: additional requirement that links the parameter-dependency of the lower and upper bounds on the Lyapunov function, stronger condition of uniform boundedness of solutions, modification and simplification of the proofs accordingl

Arrhythmogenic right ventricular cardiomyopathy associated with severe left ventricular involvement in a cat.

An 8-year-old, 4 kg, intact female, domestic shorthaired cat was referred for tachypnea and pleural effusion. A 24-h Holter recording showed numerous polymorphic ventricular premature complexes with left and right bundle branch block morphology. Echocardiographic examination revealed right atrial and ventricular dilation. The right ventricular free wall was thin and aneurysmal. The cat died 10 days after initiation of antiarrhythmic therapy. Gross and histopathological findings were consistent with arrhythmogenic right ventricular cardiomyopathy (ARVC) associated with severe left ventricular involvement

The Genetic and Environmental Effects on Diabetes in Humans and Animals: An Overview

Despite intense scrutiny the precise etiology of diabetes mellitus remains unclear. There appear to be two major forms of diabetes: juvenile-onset or insulin-dependent diabetes, and late-onset or insulin-independent diabetes; the late-onset form, in itself, may be etiologically heterogeneous. Either form may occur at any age, with a clear distinction between the two often being difficult to make. Juvenile-onset diabetes, representing 5% to 10% of all cases, is characterized by abrupt onset, clinical manifestation of hyperglycemia and ketoacidosis, and generally by a requirement for exogenous insulin; in maturity-onset diabetes plasma levels of insulin are usually normal or elevated and the abnormality in glucose metabolism results from a decrease in the number of insulin receptors rather than a deficiency of the hormone itself

On high-speed turning of a third-generation gamma titanium aluminide

Gamma titanium aluminides are heat-resistant intermetallic alloys predestined to be employed in components suffering from high mechanical stresses and thermal loads. These materials are regarded as difficult to cut, so this makes process adaptation essential in order to obtain high-quality and defect-free surfaces suitable for aerospace and automotive parts. In this paper, an innovative approach for longitudinal external high-speed turning of a third-generation Ti-45Al-8Nb- 0.2C-0.2B gamma titanium aluminide is presented. The experimental campaign has been executed with different process parameters, tool geometries and lubrication conditions. The results are discussed in terms of surface roughness/integrity, chip morphology, cutting forces and tool wear. Experimental evidence showed that, due to the high cutting speed, the high temperatures reached in the shear zone improve chip formation, so a crack-free surface can be obtained. Furthermore, the use of a cryogenic lubrication system has been identified in order to reduce the huge tool wear, which represents the main drawback when machining gamma titanium aluminides under the chosen process condition

Aquaporin 1 (Aqp1) expression in healthy dog tears

Aquaporins (AQPs) are a family of thirteen membrane proteins that play an essential role in the transport of fluids across the cell plasma membrane. Recently, the expression of AQPs in dierent ocular tissues and their involvement in the pathophysiology of eye diseases, have garnered attention. Considering that literature on AQP expression in the lacrimal glands and their secretion is scarce, we aimed to characterise AQP1 expression in the tears of healthy dogs using two tear collection methods (Schirmer tear strips (STS) and ophthalmic sponges (OS)). Fifteen healthy dogs, free of ophthalmic diseases, were included in the study. Tear collection was performed by using STS in one eye and OS in the other. After the extraction of proteins from the tears, the expression of AQP1 was analysed by Western blotting. AQP1 was expressed as a band of 28 kDa. In addition, dierences were observed in the expression of AQP1 and in the correlation between tear volume and protein concentration, in tears collected by the two dierent methods. Our results suggest that AQP1 has a specific role in tear secretion; further research is required to assess its particular role in the function of the ocular surface in eye physiology and pathology

Eigenvector Centrality Distribution for Characterization of Protein Allosteric Pathways

Determining the principal energy pathways for allosteric communication in biomolecules, that occur as a result of thermal motion, remains challenging due to the intrinsic complexity of the systems involved. Graph theory provides an approach for making sense of such complexity, where allosteric proteins can be represented as networks of amino acids. In this work, we establish the eigenvector centrality metric in terms of the mutual information, as a mean of elucidating the allosteric mechanism that regulates the enzymatic activity of proteins. Moreover, we propose a strategy to characterize the range of the physical interactions that underlie the allosteric process. In particular, the well known enzyme, imidazol glycerol phosphate synthase (IGPS), is utilized to test the proposed methodology. The eigenvector centrality measurement successfully describes the allosteric pathways of IGPS, and allows to pinpoint key amino acids in terms of their relevance in the momentum transfer process. The resulting insight can be utilized for refining the control of IGPS activity, widening the scope for its engineering. Furthermore, we propose a new centrality metric quantifying the relevance of the surroundings of each residue. In addition, the proposed technique is validated against experimental solution NMR measurements yielding fully consistent results. Overall, the methodologies proposed in the present work constitute a powerful and cost effective strategy to gain insight on the allosteric mechanism of proteins